Idiopathic thrombocytopenic purpura in pregnancy: a single institutional experience with maternal and neonatal outcomes


Ali R., Ozkalemkas F., Ozcelik T., Ozkocaman V., Ozan U., Kimya Y., ...Daha Fazla

ANNALS OF HEMATOLOGY, cilt.82, sa.6, ss.348-352, 2003 (SCI-Expanded) identifier identifier identifier

  • Yayın Türü: Makale / Tam Makale
  • Cilt numarası: 82 Sayı: 6
  • Basım Tarihi: 2003
  • Doi Numarası: 10.1007/s00277-003-0665-6
  • Dergi Adı: ANNALS OF HEMATOLOGY
  • Derginin Tarandığı İndeksler: Science Citation Index Expanded (SCI-EXPANDED), Scopus
  • Sayfa Sayıları: ss.348-352
  • Anahtar Kelimeler: idiopathic thrombocytopenic purpura (ITP), pregnancy, SPLENECTOMY, MANAGEMENT, PATHOPHYSIOLOGY
  • Bursa Uludağ Üniversitesi Adresli: Evet

Özet

We observed 13 pregnant women of 70 females with idiopathic thrombocytopenic purpura (ITP) from January 1992 through September 2002. Thirteen mothers with ITP gave birth to twelve babies and two fetuses died. One of the pregnancies produced twins. Seven of the cases were diagnosed with ITP before pregnancy and six during pregnancy. One of the thirteen pregnancies was complicated by preeclampsia, one by ablatio placentae, and one by intrauterine death. Seven mothers received corticosteroid treatment, four high-dose immunoglobulin therapies, and one underwent splenectomy in the second trimester of gestation. At the time of delivery six mothers had normal platelet counts and seven had low platelet counts. Nine deliveries were by vaginal route and four were by cesarean section. Eleven infants were born with normal platelet counts and one was thrombocytopenic at the time of delivery. No infant showed any clinical signs of hemorrhage and there were no neonatal complications. Two fetuses died; one of them because of ablatio placentae and the other was intrauterine dead. In conclusion, ITP in pregnancy requires the management of two patients, the mother and her baby; hence, the close collaboration of a multidisciplinary group composed of a hematologist, obstetrician, anesthesiologist, and neonatologist is essential.