Malignant giant-cell tumor of bone with lymph node involvement in a cat

AKKOÇ A. , SÖNMEZ G. , Yanik K., ALASONYALILAR DEMİRER A. , GÜL SATAR N. Y. , Ferreras Estrada M. C.

TURKISH JOURNAL OF VETERINARY & ANIMAL SCIENCES, vol.35, no.5, pp.369-373, 2011 (Journal Indexed in SCI) identifier identifier

  • Publication Type: Article / Article
  • Volume: 35 Issue: 5
  • Publication Date: 2011
  • Doi Number: 10.3906/vet-1011-573
  • Page Numbers: pp.369-373


The present study describes giant-cell tumor of bone (GCToB) with lymph node involvement in a 5-year-old crossbred cat. The animal was referred to the surgery clinic with progressive subcutaneous swelling in the left proximal femoral region, severe lameness, constipation, and dysuria. A moderately firm, subcutaneous, palpable mass, 9 cm in diameter, was observed, and biopsy samples were taken. Histopathologically, the mass was constituted by ovoid-shaped mononuclear cells intermixed with many multinucleated giant cells (MGC). Immunohistochemically, the giant cells were positively stained with antivimentin, and the same cells were negative for antidesmin and anti-S100 staining. Tartrate-resistant acid phosphatase (TRAP) activity in tumor cells was evaluated and the tumor was diagnosed as malignant GCToB; the cat was euthanized. Macroscopically, while the regional lymph nodes were intact, giant cells were found in the left popliteal lymph node during microscopy. Although a few cases of GCToB have been reported in cats, the case herein displays, for the first time, evidence of lymph node involvement during the process of metastasis.