Helicobacter pylori Infection in Children: Nutritional Status and Associations with Serum Leptin, Ghrelin, and IGF-1 Levels


Erdemir G., ÖZKAN T. M. , ÖZGÜR T. , Altay D., ÇAVUN S. , Goral G.

HELICOBACTER, vol.21, no.4, pp.317-324, 2016 (Journal Indexed in SCI) identifier identifier identifier

  • Publication Type: Article / Article
  • Volume: 21 Issue: 4
  • Publication Date: 2016
  • Doi Number: 10.1111/hel.12288
  • Title of Journal : HELICOBACTER
  • Page Numbers: pp.317-324
  • Keywords: Childhood, H, pylori, growth, leptin, ghrelin, BODY-MASS INDEX, GROWTH-FACTOR, PEPTIC-ULCERATION, RISK-FACTORS, STOMACH, EPIDEMIOLOGY, MALNUTRITION, ADOLESCENTS, CHILDHOOD, GASTRITIS

Abstract

BackgroundHelicobacter pylori is associated with gastrointestinal diseases such as gastritis, peptic ulcers, malignancy and lymphoma, and extra-gastrointestinal conditions. H. pylori infection is negatively associated with children's growth. Chronic inflammation of the stomach that results in the loss of appetite and, dysregulation of neuroendocrine hormones such as leptin, and ghrelin are the probable reasons of this negative association. The objective of this study is to determine the serum levels of leptin, ghrelin, and IGF-1 in H. pylori-infected children and their relations with growth.