Growth of Staphylococcus aureus, Candida albicans, Escherichia coli and Pseudomonas aeruginosa in Propofol, Thiopental and a 1:1 Propofol-Thiopental Mixture

TOPAL A. , BİLGİN H. , ÖZAKIN C. , Gedikoglu S., GÜL SATAR N. Y.

JOURNAL OF ANIMAL AND VETERINARY ADVANCES, vol.9, no.10, pp.1432-1435, 2010 (Journal Indexed in SCI) identifier identifier

  • Publication Type: Article / Article
  • Volume: 9 Issue: 10
  • Publication Date: 2010
  • Doi Number: 10.3923/javaa.2010.1432.1435
  • Page Numbers: pp.1432-1435


Extrinsic contamination of propofol is thought to be a source of postoperative sepsis. Researchers studied growth of Staphylococcus aureus, Pseudomonas aeruginosa, Escherichia coli and Candida albicans in propofol, thiopental and in a 1:1 propofol-thiopental mixture. All microorganisms were taken from standard stock cultures. Half of the samples were incubated at 20 degrees C and the rest were stored at 4 degrees C for 120 h. Growth of microorganisms in each solution was compared by counting the number of the Colony-Forming Units (CFUs) at 0, 3, 6, 24, 72 and 120 h. Propofol supported the growth of all four microorganims at both temperatures. In contrast, thiopental and the 1:1 propofol-thiopental mixture exhibited markedly bactericidal properties on E. coli, C. albicans and P. aeruginosa and bacteriostatic effect on S. aureus.