Intracerebroventricularly injected nesfatin-1 activates central cyclooxygenase and lipoxygenase pathways

Guvenc-Bayram G., Altinbas B., Iqbal A., Cerci E., Udum D., Yılmaz M. S., ...Daha Fazla

AUTONOMIC NEUROSCIENCE-BASIC & CLINICAL, cilt.226, 2020 (SCI-Expanded) identifier identifier identifier

  • Yayın Türü: Makale / Tam Makale
  • Cilt numarası: 226
  • Basım Tarihi: 2020
  • Doi Numarası: 10.1016/j.autneu.2020.102670
  • Dergi Adı: AUTONOMIC NEUROSCIENCE-BASIC & CLINICAL
  • Derginin Tarandığı İndeksler: Science Citation Index Expanded (SCI-EXPANDED), Scopus, Academic Search Premier, BIOSIS, CAB Abstracts, EMBASE, MEDLINE, Veterinary Science Database
  • Anahtar Kelimeler: Nesfatin-1, Cyclooxygenase, Lipoxygenase, Hypothalamus, Intracerebroventricular, CRITICAL HEMORRHAGIC HYPOTENSION, PHOSPHOLIPASE A(2) ACTIVATOR, ENDOGENOUS CENTRAL HISTAMINE, BRAIN THROMBOXANE A(2), ARACHIDONIC-ACID, NITRIC-OXIDE, FOOD-INTAKE, INVOLVEMENT, SYSTEM, RATS
  • Bursa Uludağ Üniversitesi Adresli: Evet

Özet

Nesfatin-1 is a multifunctional neuropeptide having crucial autonomic roles. It is well known that nesfatin-1 collaborates with other central neuromodulatory systems, such as central corticotropin-releasing hormone, melanocortin, oxytocin, and cholinergic systems to show its autonomic effects. Central arachidonic acid cascade plays an important role to provide the homeostasis by exhibiting similar autonomic effects to nesfatin-1. Based on these similarities, the current study was designed to show the effects of intracerebroventricularly (ICV) injected nesfatin-1 on the hypothalamic arachidonic acid (AA) cascade.