A systemic infection with Streptococcus equi subsp. zooepidemicus is described in a 22-day-old female foal for the first time in Turkey. Clinically the foal was in poor condition and had severe pneumonia. Painful swellings of the carpal and tarsal joints were evident. Examination of the dam revealed clinical mastitis. Postmortem histopathological and microbiological examinations of samples from the foal revealed a disseminated infection with S. equi subsp. zooepidemicus. The causative agent was also recovered in pure culture from a milk sample of the mare.