Conventional Amphotericin B Associated Nephrotoxicity in Patients With Hematologic

Gursoy V., ÖZKALEMKAŞ F., ÖZKOCAMAN V., Yegen Z. S., PINAR İ. E., ENER B., ...Daha Fazla

CUREUS, cilt.13, sa.7, 2021 (ESCI) identifier identifier

  • Yayın Türü: Makale / Tam Makale
  • Cilt numarası: 13 Sayı: 7
  • Basım Tarihi: 2021
  • Doi Numarası: 10.7759/cureus.16445
  • Dergi Adı: CUREUS
  • Derginin Tarandığı İndeksler: Emerging Sources Citation Index (ESCI)
  • Anahtar Kelimeler: conventional amphotericin b, nephrotoxicity, hematological malignancy, hypokalemia, fungal infections, ACUTE-RENAL-FAILURE, RISK-FACTORS, PREVENTION, THERAPY
  • Bursa Uludağ Üniversitesi Adresli: Evet

Özet

Introduction: Amphotericin B (AmB-d) is one of the most effective therapeutic options against frequently life-threatening systemic fungal infections in patients with hematologic malignancies. However, significant adverse effects including nephrotoxicity associated with its use limit its more widespread use. The objectives of our study were to determine the incidence of AmB-d associated nephrotoxicity, to evaluate clinical and epidemiological characteristics of patients, and to support the notion that conventional amphotericin B remains a valid therapeutic option among hematologic patients with proper patient selection.