Changes in salivary analytes in canine parvovirus: A high-resolution quantitative proteomic study


Franco-Martinez L., Tvarijonaviciute A., Horvatic A., Guillemin N., Joaquin Ceron J., Escribano D., ...More

COMPARATIVE IMMUNOLOGY MICROBIOLOGY AND INFECTIOUS DISEASES, vol.60, pp.1-10, 2018 (Journal Indexed in SCI) identifier identifier identifier

  • Publication Type: Article / Article
  • Volume: 60
  • Publication Date: 2018
  • Doi Number: 10.1016/j.cimid.2018.09.011
  • Title of Journal : COMPARATIVE IMMUNOLOGY MICROBIOLOGY AND INFECTIOUS DISEASES
  • Page Numbers: pp.1-10
  • Keywords: Bioinformatics, Biomarker, Canine parvovirosis, Dog, Label-based proteomics, Saliva, HISTIDINE-RICH GLYCOPROTEIN, ACUTE-PHASE PROTEINS, DOGS, BIOMARKERS, INFECTION, IDENTIFICATION, DIAGNOSIS, ENTERITIS, LIPOCALIN, SERUM

Abstract

The present study evaluated the changes in salivary proteome in parvoviral enteritis (PVE) in dogs through a high-throughput quantitative proteomic analysis. Saliva samples from healthy dogs and dogs with severe parvovirosis that survived or perished due to the disease were analysed and compared by Tandem Mass Tags (TMT) analysis. Proteomic analysis quantified 1516 peptides, and 287 (corresponding to 190 proteins) showed significantly different abundances between studied groups. Ten proteins were observed to change significantly between dogs that survived or perished due to PVE.