Kainic acid activates oxytocinergic neurons through non-NMDA glutamate receptors
INTERNATIONAL JOURNAL OF NEUROSCIENCE, cilt.116, sa.5, ss.587-600, 2006 (SCI-Expanded, Scopus)
- Yayın Türü: Makale / Tam Makale
- Cilt numarası: 116 Sayı: 5
- Basım Tarihi: 2006
- Doi Numarası: 10.1080/00207450600592123
- Dergi Adı: INTERNATIONAL JOURNAL OF NEUROSCIENCE
- Derginin Tarandığı İndeksler: Science Citation Index Expanded (SCI-EXPANDED), Scopus
- Sayfa Sayıları: ss.587-600
- Anahtar Kelimeler: CNQX, immunohistochemistry, kainate, oxytocin, PVN, SON, METHYL-D-ASPARTATE, HYPOTHALAMIC PARAVENTRICULAR NUCLEUS, SUBUNIT MESSENGER-RNAS, RAT HYPOTHALAMUS, SUPRAOPTIC NUCLEUS, MAGNOCELLULAR NEURONS, SYNAPTIC CURRENTS, LACTATING RAT, IN-VITRO, EXPRESSION
- Bursa Uludağ Üniversitesi Adresli: Evet
Özet
The present study assessed if kainic acid activates oxytocinergic neurons and this activation is blocked by 6- cyano- 7- nitroquinoxaline- 2,3- dione ( CNQX). Dual immunohistochemistry for oxytocin and c- Fos showed that oxytocin neurons in SON and PVN express c- Fos following kainic acid administration, a significant increase when compared to the control group. Administration of CNQX prior to kainic acid caused a significant reduction. The results suggested the participation of non- NMDA receptors in the regulation of oxytocin neurons because the administration of kainic acid activates these neurons and this activation is blocked by CNQX administration.