Correlation between Ubiquitin E3 Ligases (SIAHs) and Heat Shock Protein 90 in Breast Cancer Patients


Takanlou L. S., ÇEÇENER G., Takanlou M. S., Nazlioglu H. O., Unlu H. T., IŞIK Ö., ...More

IRANIAN JOURNAL OF PUBLIC HEALTH, vol.51, no.8, pp.1836-1846, 2022 (SCI-Expanded) identifier identifier

  • Publication Type: Article / Article
  • Volume: 51 Issue: 8
  • Publication Date: 2022
  • Doi Number: 10.18502/ijph.v51i8.10270
  • Journal Name: IRANIAN JOURNAL OF PUBLIC HEALTH
  • Journal Indexes: Science Citation Index Expanded (SCI-EXPANDED), Social Sciences Citation Index (SSCI), Scopus, CAB Abstracts, CINAHL, Veterinary Science Database, Directory of Open Access Journals
  • Page Numbers: pp.1836-1846
  • Keywords: Breast cancer, Invasive ductal carcinoma, Ubiquitin-protein ligases, IN-ABSENTIA HOMOLOG, HSP90 EXPRESSION, INHIBITION, BIOMARKERS, ROLES, PROGRESSION, RESISTANCE, RESPONSES, PATHWAY, COMPLEX
  • Bursa Uludag University Affiliated: Yes

Abstract

Background: Breast cancer is a heterogeneous disease and differences in the expression levels of the ER, PR, and HER2 the triplet of established biomarkers used for clinical decision-making have been reported among breast cancer patients. Furthermore, resistance to anti-estrogen and anti-HER2 therapies emerges in a considerable rate of breast cancer patients, and novel drug therapies are required. Several anomalous signaling pathways have been known in breast cancer have been known; heat shock protein 90 (HSP90) is one of the most plenty proteins in breast cells. The family of ubiquitin ligases such as SIAH1 and SIAH2 is known to specifically target misfolded proteins to the proteasome; also, they have been illustrated to play a role in RAS signaling and as an essential downstream signaling component required for EGFR/HER2 in breast cancer.