Morphometric Shape Analysis of Corpus Callosum in Children With Down Syndrome

ERDEMLİ GÜRSEL B., ERCAN İ., Sahin I., ÖNGEN G.

CLINICAL PEDIATRICS, vol.63, no.6, pp.815-821, 2024 (SCI-Expanded) identifier identifier identifier

  • Publication Type: Article / Article
  • Volume: 63 Issue: 6
  • Publication Date: 2024
  • Doi Number: 10.1177/00099228231196933
  • Journal Name: CLINICAL PEDIATRICS
  • Journal Indexes: Science Citation Index Expanded (SCI-EXPANDED), Scopus, Academic Search Premier, CAB Abstracts, CINAHL, EBSCO Education Source, EMBASE, Public Affairs Index, Veterinary Science Database
  • Page Numbers: pp.815-821
  • Keywords: Down syndrome, corpus callosum, splenium, shape analysis, BRAIN, MORPHOLOGY
  • Bursa Uludag University Affiliated: Yes

Abstract

Down syndrome (DS) is characterized by varying degrees of mental retardation and delay in neurocognitive functions. Herein, we analyzed the morphometric shape of the corpus callosum (CC) in children with DS. Twenty-three DS cases underwent magnetic resonance imaging and have grossly normal CC, and 23 control group cases were included in this retrospective study (2012-2020). The CC was obtained from T2-weighted mid-sagittal images, and certain anatomical points were marked on the CC. Statistical geometric shapes and deformations of CC were evaluated for both groups. The age range of patients with DS and control group was 6 to 42 months. A statistically significant difference was found in the shape of CC between the groups (P < .001). Deformation was most evident in the splenium in the DS group.