Mitoquinone attenuates blood-brain barrier disruption through Nrf2/PHB2/OPA1 pathway after subarachnoid hemorrhage in rats


Zhang T., Xu S., Wu P., Zhou K., Wu L., Xie Z., ...More

EXPERIMENTAL NEUROLOGY, vol.317, pp.1-9, 2019 (SCI-Expanded) identifier identifier identifier

  • Publication Type: Article / Article
  • Volume: 317
  • Publication Date: 2019
  • Doi Number: 10.1016/j.expneurol.2019.02.009
  • Journal Name: EXPERIMENTAL NEUROLOGY
  • Journal Indexes: Science Citation Index Expanded (SCI-EXPANDED), Scopus
  • Page Numbers: pp.1-9
  • Keywords: Mitoquinone, NF-E2-related factor 2, Prohibitin 2, Optic atrophy 1, Blood-brain barrier disruption, Subarachnoid hemorrhage, POSSIBLE INVOLVEMENT, INJURY, PROHIBITINS, INHIBITION, APOPTOSIS, NUCLEAR, DISEASE, EDEMA
  • Bursa Uludag University Affiliated: No

Abstract

Background and purpose: Mitochondrial dysfunction is involved in the mechanism of early brain injury (EBI) following subarachnoid hemorrhage (SAH). Blood-brain barrier disruption is a devastating outcome in the early stage of SAH. In this study, we aimed to investigate the role of a mitochondria-related drug Mitoquinone (MitoQ) in blood-brain barrier disruption after SAH in rats.