Retrospective Evaluation of Hemophagocytic Lymphohistiocytosis Cases Treated


Temuroglu A., SEZGİN EVİM M. , Sevinir B., Baytan B., Guler S. , Gunes A. M.

GUNCEL PEDIATRI-JOURNAL OF CURRENT PEDIATRICS, vol.18, no.1, 2020 (Journal Indexed in ESCI) identifier identifier

  • Publication Type: Article / Article
  • Volume: 18 Issue: 1
  • Publication Date: 2020
  • Title of Journal : GUNCEL PEDIATRI-JOURNAL OF CURRENT PEDIATRICS

Abstract

INTRODUCTION: Hemophagocytic lymphohistiocytosis (HLH) is a rare inflammatory syndrome resulting from uncontrolled proliferation in the monocyte / macrophage system. It is divided into two classes as familial (primary) and secondary. Since the rate of consanguineous marriage in our country is high with 29.2%, the frequency of HLH is also increasing. Secondary HLH can be seen at any age, but its true incidence is unknown. It can accompany malignancies, infections and inflammatory processes. Major clinical findings are persistent high fever, cytopenia, splenomegaly and / or hepatomegaly. The first finding is usually fever. The goal of treatment is to stop abnormal inflammation and treat the underlying cause.