The aim of the this study was to observe possible changes in coagulation profiles in dogs with septic shock. A total of 30 dogs (control group n=10, test group n=20) were used as materials in this study. Although different diseases leading to septic shock were diagnosed in dogs in the test group, dogs were selected on the basis of septic shock criteria such as fever or hypothermia, hypotension. leukopenia or leukocytosis and thrombocytopenia. In addition to the results of rutine clinical and laboratory examination, prothrombin time (PT), activated partial thromboplastin time (aPTT), antithrombin III (AT III), fibrinogen and fibrin split products (FSP), as well as factors (F-VIII and F-IX) playing role in the coagulation mechanism,were evaluated.