C-erb-B2 (Her2/neu) Expression Rate And its Association with Clinicopathologic Parameters in Gastric Cancer
UHOD-ULUSLARARASI HEMATOLOJI-ONKOLOJI DERGISI, cilt.22, sa.3, ss.156-162, 2012 (SCI-Expanded, Scopus, TRDizin)
- Yayın Türü: Makale / Tam Makale
- Cilt numarası: 22 Sayı: 3
- Basım Tarihi: 2012
- Doi Numarası: 10.4999/uhod.12044
- Dergi Adı: UHOD-ULUSLARARASI HEMATOLOJI-ONKOLOJI DERGISI
- Derginin Tarandığı İndeksler: Science Citation Index Expanded (SCI-EXPANDED), Scopus, TR DİZİN (ULAKBİM)
- Sayfa Sayıları: ss.156-162
- Bursa Uludağ Üniversitesi Adresli: Hayır
Özet
We aimed to investigate the frequency of c-erb-B2 expression rate and its association with clinicopathological parameters in our gastric carcinoma series to make a contribution to emerging data on this oncogene. One hundred thirty-nine gastric adenocarcinoma patients underwent total gastrectomy between years 2006 and 2011 were selected to the study. C-erb-B2 expressions were determined by using immunohistochemical and/or chromogenic in situ hybridisation methods in tumor tissues. A total of 16 (11.5%) gastric adenocarcinoma cases were found positive for c-erb-B2 expression. Out of 16 positive cases, 13 had intestinal type adenocarcinomas. C-erb-B2 overexpression was significantly associated with histologic subtype (p= 0.001), and histologic tumor grade (p= 0.001). The frequency of overexpression in intestinal subtype (21.7%) was comparable with the known rates of overexpression in breast cancer. This results indicate that C-erb-B2 expression may identify a subgroup in gastric carcinoma cases which may benefit from targeted treatment modalities among Turkish population.