Applied Biochemistry and Biotechnology - Part B Molecular Biotechnology, vol.21, no.3, pp.225-239, 2002 (SCI-Expanded)
Article / Review
Applied Biochemistry and Biotechnology - Part B Molecular Biotechnology
Science Citation Index Expanded (SCI-EXPANDED), Scopus
antibody therapy, infectious diseases, immunoglobulin, HUMAN-IMMUNODEFICIENCY-VIRUS, TUMOR-NECROSIS-FACTOR, HUMAN MONOCLONAL-ANTIBODY, PLACEBO-CONTROLLED TRIAL, INTRAVENOUS IMMUNOGLOBULIN THERAPY, BONE-MARROW TRANSPLANTATION, GRAM-NEGATIVE BACTEREMIA, B IMMUNE GLOBULIN, LIPID-A DOMAIN, SEPTIC SHOCK
Bursa Uludag University Affiliated:
Before antibiotics, sera from immune animals and humans were used to treat a variety of infectious diseases, often with successful results. After the discovery of antimicrobial agents, serum therapy for bacterial infections was rapidly forsaken. In the last two decades, problems with treatment of newly emerged, reemerged, or persistent infectious diseases necessitated researchers to develop new and/or improved antibody-based therapeutic approaches. This article reviews some information on the use of antibodies for the treatment of infectious diseases, with special reference to the most seminal discoveries and current advances as well as available treatment approaches in this field.