Akademik Veri Yönetim Sistemi
Satıcıoğlu İ. B. (Yürütücü), Altun S., Duman M., Rochat T.
AB Destekli Diğer Projeler, 2022 - 2022
Turkey was the
largest rainbow trout producer of the European countries in 2019. The bacterial
pathogen Flavobacterium psychrophilum causes the highest mortalities during
the early life stages. This project proposal aims to determine, using in
vivo experimental infection trials, the virulence of F. psychrophilum
isolates belonging to epidemic clonal complexes. The isolates were retrieved
from disease outbreaks in rainbow trout farms in Turkey between 2014 and 2018.
Data referring to these isolates, including antimicrobial susceptibility and
basic genotyping, were published in Aquaculture (Saticioglu et al., 2019) and the
Journal of Fish Diseases (Saticioglu et al., 2018). Additional relevant
phenotypic characteristics will be analyzed in vitro (hemolysis,
hydrolysis of casein, gelatin, elastin, adhesion), and genomic characteristics
(presence of virulence-associated and antimicrobial resistance genes in
complete genomes) will be determined. For the in vivo experimental
challenges, we plan to use a set of 5 F.
psychrophilum strains selected according to their in vitro
phenotypes and genomic characteristics. The experimental infections will be
carried out in rainbow trout using an immersion model developed by INRAe
(Pérez-Pascual et al. 2017; Fraslin et al. 2018), which more closely mimics the
natural route of infection. This project will help us understand the virulence
and host adaptation of F. psychrophilum and allow better control
strategies, including future vaccine studies.