The effects on taurine on oxidant and antioxidant systems in experimentally induced type 2 diabetes


Thesis Type: Postgraduate

Institution Of The Thesis: Bursa Uludağ University, FEN-EDEBİYAT FAKÜLTESİ, BİYOLOJİ, Turkey

Approval Date: 2006

Thesis Language: Turkish

Student: SEDEF ZİYANOK AYVALIK

Supervisor: Sibel Taş

Abstract:

Oxidative stress which occurs as a result of increased blood glucose and lipidlevels plays an important role in the progression of the complications of diabetes. Sincetaurine is able to reduce blood glucose and lipid levels, it is thought to decreaseoxidative stress. This study was designed to investigate the effects of taurine onhypoglycemic, oxidant and antioxidant systems in streptozotocin -nicotinamide inducedtype 2 diabetes. Subjects were made type 2 diabetes by injecting nicotinamide(45mg/kg) intraperitoneally 15 min before injection of streptozotocin (65 mg/kg).Taurine (1%) was supplemented in drinking water for 5 weeks.Thirty two male Wistarrats were randomly divided into four groups; control (C), control + taurine (C + T),diabet (D), diabet + taurine (D + T). Serum trigliseride, tissue and plasmamalondialdehyde levels were observed to be significantly reduced while serum totalantioxidant capacity were significantly increased in C + T group when compared withcontrol group. Serum total cholesterol and triglyceride, blood glucose, plasma and tissuemalondialdehyde levels were signigicantly reduced while serum insulin, bloodglutathione peroxidase and erythrocyte superoxide dismutase, serum paraoxonase andarylesterase activities were significantly increased in D + T group when compared withD group.In conclusion, because of its antihyperglycemic and antihyperlipidemic andantioxidant features, taurine plays a protective and preventive role against oxidativestress in type 2 diabetes and it can be used to supplement and support the treatment ofdiabetes.