Evaluation of glucose metabolism in cows with left displacement of abomasum


Thesis Type: Doctorate

Institution Of The Thesis: Bursa Uludağ University, Sağlık Bilimleri Enstitüsü, Turkey

Approval Date: 2010

Thesis Language: Turkish

Student: Zafer Mecitoğlu

Supervisor: SEZGİN ŞENTÜRK

Abstract:

Present study aimed to investigate the role of glucose metabolism and insulin resistance on left displacement of abomasum, a problem of postpartum dairy cows of which incidence is gradually rising.Material of this study consist of totally 40 cows of which 20 were diagnosed left displacement of abomasum (LDA), and 20 were healthy. All the cows used in the study were selected from same herd and mean of ages, lactation, calf birth weight, production group and body condition scores and rations of two groups were same.After clinical examination, both groups were blood sampled for comparison of haematological (total leukocyte, neutrophile, lymphocyte, monocyte, eosinophile, basophile, erythrocyte, haemoglobin, haematocrit, MCH, MCHC, thrombocyte, PCT) and biochemical (albumin, ALP, ALT, amylase, total bilirubin, BUN, calcium, phosphorus, creatinin, globulin, sodium, potasium, TP, glucose, insulin, fructosamine, GGT, AST and BHBA) parameters.Although haemathological evaluation revealed statistical significance between total leukocyte (p<0,001), neutrophile (p<0,01), lymphocyte (p<0,001), monocyte (p<0,001), eosinophile (p<0,001), erythrocyte (p<0,01), haemoglobin (p<0,001), haematocrit (p<0,001), MCH (p<0,05), MCHC (p<0,001) and biochemical evaluation between albumin (p<0,05), calcium (p<0,05), GGT (p<0,001), AST (p<0,001) and BHBA (p<0,01) levels, significance between glucose, insulin and fructosamine levels which are related to glucose metabolism could not be observed. Despite results of the study revealed no difference in glucose, insulin, and fructosamine levels between two groups, high BHBA levels in cows with displaced abomasum could indicate insulin resistance. Likewise, study revealed significant difference of liver function between two groups, which could be closely related to insulin resistance. Further studies, investigating the role of insulin resistance, glucose metabolism and hepatic lipidosis on etiology of displacements of abomasum could be a new frontier to predict and prevent displacements of abomasum.