Investigation on levels of active substances of some expired veterinary chemotherapeutic drugs


Thesis Type: Postgraduate

Institution Of The Thesis: Bursa Uludağ University, Sağlık Bilimleri Enstitüsü, Turkey

Approval Date: 1998

Thesis Language: Turkish

Student: Fatoş Atasoy

Supervisor: SONGÜL SONAL

Abstract:

The term "expire date" is defined as "the last date which drugs usable before" by World Health Organization (WHO). In our country, it has been obligatory to put the expire date on all packages of drugs. For determining expire date of drugs, various factors are evaluated. At the end of expire date the amount of active substance will be decreased by the effects of external heat, air, light, and the interactions between the ingredients and the active substances in drug combinations. In this study, some expired veterinary preparations of ampicillin, sulphadiazin - trimethoprime and oxytetracycline were analyzed for their active principles by the methods in the Turkish Pharmacopoeia, British Veterinary Pharmacopoeia and United States Pharmacopoeia. Amongst the 38 samples of pharmaceutical preparations analyzed only 8 samples (23%) were found to contain active substance below the pharmacopoeia limits. The maximal loss of active substance rate was 15.83% for ampicillin samples. This rate was 62% for trimethoprim and 80% for sulphadiazin. Maximum active substance loss rate was 23% for oxytetracycline samples and 27.7% was out of pharmacopoeia limits. IllIt was concluded that the decreases in the active substances of the expired antimicrobial drug samples are in pharmacopoeia limits and they are mostly renewable.