Thesis Type: Postgraduate
Institution Of The Thesis: Bursa Uludağ University, Sağlık Bilimleri Enstitüsü, Turkey
Approval Date: 1998
Thesis Language: Turkish
Student: Fatoş Atasoy
Supervisor: SONGÜL SONALAbstract:
The term "expire date" is defined as "the last date which drugs usable before" by World Health Organization (WHO). In our country, it has been obligatory to put the expire date on all packages of drugs. For determining expire date of drugs, various factors are evaluated. At the end of expire date the amount of active substance will be decreased by the effects of external heat, air, light, and the interactions between the ingredients and the active substances in drug combinations. In this study, some expired veterinary preparations of ampicillin, sulphadiazin - trimethoprime and oxytetracycline were analyzed for their active principles by the methods in the Turkish Pharmacopoeia, British Veterinary Pharmacopoeia and United States Pharmacopoeia. Amongst the 38 samples of pharmaceutical preparations analyzed only 8 samples (23%) were found to contain active substance below the pharmacopoeia limits. The maximal loss of active substance rate was 15.83% for ampicillin samples. This rate was 62% for trimethoprim and 80% for sulphadiazin. Maximum active substance loss rate was 23% for oxytetracycline samples and 27.7% was out of pharmacopoeia limits. IllIt was concluded that the decreases in the active substances of the expired antimicrobial drug samples are in pharmacopoeia limits and they are mostly renewable.