Adiponectin levels in cows suffering from subclinical and clinical ketosis and evaluation of relationship between NEFA, BHBA and adiponectin

Thesis Type: Doctorate

Institution Of The Thesis: Bursa Uludağ University, Sağlık Bilimleri Enstitüsü, Turkey

Approval Date: 2014

Thesis Language: Turkish

Student: Gülşah Akgül



Aim of the presented study was to investigate the role of adiponectin on pathogenesis of ketosis in dairy cows and relationship with between NEFA, BHBA and adiponectin. Material of this study consist of totaly 45 dairy cows of which 15 were detected to be suffering from clinical ketosis, 15 subclinical ketosis and 15 healthy cows. Ketosis was diagnosed by measuring the levels of serum BHBA. Cows with serum BHBA levels of 1,4 mmol/ L≤ were classified as clinical ketosis, serum BHBA levels of 1,0≤ 1,4 as subclinical ketosis and serum BHBA levels of >1,0 mmol/L as healthy controls. After clinical examination, blood samples for evaluation of biochemical parameters ( glucose, albumin, GGT, P, Ca, BUN, NEFA, BHBA and Adiponectin) were collected from both groups. Serum, glucose, calcium, BUN, NEFA and adiponectin levels were differ significantly between HC and CK groups. Also glucose, calcium, BUN, NEFA and adiponectin levels of healthy controls and subclinical ketosis groups were significantly different. There was not any difference between albumin and GGT levels between both groups. Adiponectin levels were significantly (p< 0,001) lower in both clinical ketosis groups and subclinical ketosis groups when compared to healthy controls group. Result of the study indicates that adiponectin could be used as a diagnostic tool for detection of ketosis and that adiponectin and therefore insulin resistance plays a major role in pathogenesis of the disease. As a result of this study, we supposed that contribute the role of Adiponectin on pathogenesis of ketosis in dairy cows and adiponectin levels on clinical and subclinical ketosis to be lower than control gropus because due to developing insulin resistance of during the ketosis which causing significant losses of considerable in our country and around the world, reserved a place in the field of veterinary medicine.