Brassica Nigra L. plant pollen treatments in experimentally induced type 1 diabetic rats: effects on the oxidative and antioxidative systems

Thesis Type: Postgraduate

Institution Of The Thesis: Bursa Uludağ University, FEN-EDEBİYAT FAKÜLTESİ, BİYOLOJİ, Turkey

Approval Date: 2015

Thesis Language: Turkish


Supervisor: Sibel Taş


This study was designed to investigate the effects of Brassica nigra L. plant pollens on blood glucose, oxidant and antioxidant systems in streptozotocin induced type 1 diabetes. Type 1 diabetes were constituted with injection intraperitoneally one dose of stretozotocin (65mg/kg). 40 male Wistar rats were randomly divided into four groups; control (C), control + Brassica nigra L. pollen (C + BN), diabetes (D), diabetes + Brassica nigra L. pollen (D + BN). Serum triglyceride, tissue malondialdehyde levels were observed to be significantly reduced while blood glutathione peroxidase, erythrocyte superoxide dismutase and serum paraoxonase activities were significantly increased in C + BN group when compared with C group. Serum total cholesterol and triglyceride, blood glucose, plasma and tissue malondialdehyde levels were significantly reduced while serum insulin, erythrocyte superoxide dismutase, serum paraoxonase and arylesterase activities were significantly increased in D + BN group when compared with D group. In conclusion, in this study we found out that Brassica nigra L. plant pollens antihyperglycemic and antihyperlipidemic and antioxidant features, and it has a protective and preventive effect against oxidative stress in type 1 diabetes.