Comprehensive antigenotoxic profile of endemic Cirsium steriolepis Petrak extracts against hydrogen peroxide induced toxicity

Bayhan H., Dogan S., Yilmaz Kardas B., Diken M. E., Dirmenci T., ÇELİKLER KASIMOĞULLARI S.

Food Science and Biotechnology, 2024 (SCI-Expanded) identifier identifier

  • Yayın Türü: Makale / Tam Makale
  • Basım Tarihi: 2024
  • Doi Numarası: 10.1007/s10068-024-01555-7
  • Dergi Adı: Food Science and Biotechnology
  • Derginin Tarandığı İndeksler: Science Citation Index Expanded (SCI-EXPANDED), Scopus, Agricultural & Environmental Science Database, Biotechnology Research Abstracts, CAB Abstracts, Compendex, Food Science & Technology Abstracts, INSPEC, Veterinary Science Database
  • Anahtar Kelimeler: Chromosome aberration, Cirsium steriolepis Petrak, In vitro, In vivo, Micronucleus, Sister chromatid exchange
  • Bursa Uludağ Üniversitesi Adresli: Evet

Özet

Cyto/genotoxicity have been widespread utilized for the safety risk assessment of synthetic/natural chemicals. Plants can protect organisms from harmful effects of xenobiotics. On the other hand, plants can extract toxic molecules from the environment which may disrupt mitosis and cytokinesis. However, the precise role of Cirsium steriolepis during this process is unknown. We showed that steriolepis didn’t cause cyto/genotoxicity. Findings showed powerful inhibition in micronucleus formation and they are safe for healthy human lymphocytes in terms of their capacity to generate chromosomal aberrations. They caused significant increases in sister chromatid exchange (SCE) compared to control but they were able to decrease SCE frequency caused by H2O2. Additionally, the antibacterial efficiencies of the samples against Escherichia coli and Staphylococcus aureus were up to 50% of the effectivity of penicillin/streptomycin. Steriolepis was able to protect the organism from the oxidative damage and didn’t affect the normal developmental phases of Drosophila melanogaster.